take care of意为“照顾”,“照料”,侧重于负有责任 Don't worry,I can take good care of your dog while you are out. take care意为“保重”,“当心”,“留心”。 Take care!The ice is thin.
look after 一般情况下可替换take care of,在意思上强调看管或照料 I'm sorry I can't go to your birthday party, because I have to look after my mother ,she is ill in hospital.